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KMID : 0191120030180020225
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Journal of Korean Medical Science
2003 Volume.18 No. 2 p.225 ~ p.230
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Bfl-1 Gene Expression in Breast Cancer: Its Relationship with other Prognostic Factors
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Ho Sung Yoon/Ho Sung Yoon
Sung Hee Hong/Hee Jun Kang/Byung Kyun Ko/Sei Hyun Ahn/Joo Ryung Huh
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Abstract
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The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA drawn from 30 breast cancer tissues to compare the expression of the Bfl-1 gene with other prognostic factors. The median relative ratio was 3.0 (range, 0.12-26.83) and the Bfl-1 gene expression rate was 36.7% (11/30). There was no statistically significant relationship between the clinicopathologic parameters of patients and the expression value of Bfl-1 gene. The level of Bfl-1 gene expression was higher in more advanced breast cancers than in early cancers. There was no significant relationship between the expression values and currently acknowledged prognostic factors, but a higher expression pattern was noticed in the groups of positive hormone receptors and negative p53 and negative c-erbB2, albeit statistically not significant. It seems that the increased expression of the Bfl-1 gene serves as a contributory factor in breast cancer, in the same way that another group of genes, the Bcl-2 family, contributes to apoptosis.
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KEYWORD
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Breast Neoplasms, Bfl-1, Prognosis, Reverse Transcriptase Polymerase Chain Reaction,
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